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doi: 10.3389/fimmu.2025.1686175 Summary Keywords COPD, ferroptosis, immune-metabolic crosstalk, lipid peroxidation, mitochondrial dynamics, precision inhalation therapy Citation Ni F-X, Chen H-H, Jiang Z-B and Huang D-H (2026) Ironing out COPD: ferroptosis-driven immune dysregulation, metabolic rewiring, and precision therapeutic opportunities

Emerging/Translational Insights Metabolic health targets

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It consistently modulates common pathological processes including oxidative stress, inflammation, fibrosis, metabolic dysfunction, abnormal apoptosis, and hormonal imbalance (Woo et al., 2021