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The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

The toxicokinetics of APAP can be altered by genetics, dose, diet, age, alcohol and other factors, and these factors make translating biomarkers discovered in omics nonclinical studies to the clinic challenging

Follow the recommended duration of use as specified on the packaging or as advised by a healthcare professional

When a person stops taking the medication, its effects halt, too, and a person may return to their previous calorie consumption