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GLP-1R activation of neuroprotective pathways in neurons, microglia and astrocytes has also been reported: improvements in overall cognition, learning and motor function potentially associated with GLP-1RA administration in Alzheimers disease and Parkinsons disease may be mediated not only by their amyloid pathology-ameliorating properties (A, tau and -synuclein), but also the suppression of Ca 2+ deregulation and endoplasmic reticulum stress, anti-inflammatory activity, blockage of oxidative stress, mitochondrial dysfunction and apoptosis pathways, enhancements in the neuronal insulin sensitivity and energy metabolism, functional improvements in autophagy and mitophagy, elevated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis, and neurogenesis 36

L-arginine supplementation can lower blood pressure and should be used cautiously in individuals taking antihypertensive medications or those with existing hypotension

Neurochemical changes over time Thalamus GABA levels in the thalamus showed a significant effect of group (F(1,26.6) = 4.95, p = 0.01, p B = 0.03) and a significant group by timepoint interaction (F(2,26.6) = 6.10, p = 0.007, p B = 0.021)

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