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About 12% of global health care expenditure (727 billion USD) is spent on diabetes
In clinical trials, participants lost an average of 15% of their body weight over 68 weeks
The term describes the visible facial aging that can accompany rapid, significant weight loss, characterized by: Hollowed, sunken cheeks where fullness once existed Prominent nasolabial folds (lines from nose to mouth corners) that deepen dramatically Jowl formation or worsening along the jawline Under-eye hollows and dark circles that create a tired appearance Temple hollowing that creates a gaunt, skeletal look Marionette lines extending from mouth corners downward Loose, sagging skin especially around the neck and lower face Increased wrinkles and crepiness from loss of skin elasticity According to a 2025 systematic review published in Plastic and Reconstructive Surgery , Ozempic face describes exaggerated volume loss from semaglutide therapy, resulting in advanced facial aging that has led to a measurable increase in facial restoration procedures Daneshgaran et al., 2025
Long-Term Healthcare Monitoring Because semaglutide treatment often involves dosage progression stages, healthcare providers generally monitor digestive tolerance, hydration, and treatment consistency carefully
