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Many patients find that tracking symptoms empowers them to take control of their side effects and accelerates their adjustment to semaglutide therapy

10.1074/jbc.M008813200 J Biol Chem

Key Takeaways: Semaglutide and Fatigue Fatigue affects approximately 10% to 15% of people taking semaglutide Usually temporary, most common during first few weeks and dose increases Primarily caused by reduced calorie intake and rapid metabolic changes, not the medication directly Often improves within 2 to 4 weeks as your body adapts to each dose Manageable through proper nutrition, hydration, sleep, and activity strategies Persistent severe fatigue warrants medical evaluation Different from dangerous fatigue that signals medical problems Most people maintain normal energy levels throughout treatment Understanding Why Semaglutide Can Cause Tiredness Before jumping to solutions, understanding the mechanisms behind semaglutide-related fatigue helps you address the root causes effectively

2.2.3 Adrenal gland Adrenal immune damage has recently been identified in patients with PCOS, coinciding with the overproduction of adrenal androgens(AA) (78, 79)