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Meanwhile, the emergence of orally active small-molecule GLP-1 receptor agonists like danuglipron and orforglipron, which are resistant to enzymatic degradation, marks a major advance in patient-friendly drug delivery

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By Day 15, alpha-fetoprotein (AFP), a hallmark of immature hepatocytes, demonstrated a notable increase, coupled with the emergence of early hepatic metabolic proteins like CYP2E1, signaling the onset of hepatic differentiation (Fig