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In addition, NE is a critical regulator of hippocampal synaptic plasticity, and its release can modulate long-lasting changes in synaptic efficacy on the basis of LTP and LTD, thereby contributing to memory consolidation and storage (Katsuki et al., 1997

Retatrutide is a triple hormone receptor agonist that targets GLP-1, GIP, and glucagon receptors

Compound 1 was isolated by silica gel column chromatography using a dichloromethane/methanol (DCM:MeOH = 60:1, V/V) eluent (yield: 80%)

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