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However, it can be more challenging, especially if weight regain has been present for several years

Typical dosing: Weekly, gradually titrated Common side effects: Nausea, reflux, constipation, diarrhea, reduced appetite Important note: Titration and follow-up can help improve tolerability and long-term success

15 Human serum albumin (HSA) and IgG have plasma half-lives of around 21 days, owing to HSA and the Fc domain of IgG interacting with the neonatal Fc receptor expressed in blood vessel endothelial cells, which rescues the proteins in the endosomes after pinocytosis, preventing them from entering the lysosomal pathway for destruction