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Current for 2025, this guide synthesizes the latest AWARD-11 trial data, includes up-to-date drug-to-drug comparisons (Ozempic, Wegovy, Zepbound), and offers practical tips for maximizing resultswhether your goal is better A1C, a smaller waistline, or both

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Unlike traditional treatments that target only CSF production, GLP-1 agonists may work through two pathways: Weight loss - a major long-term treatment for IIH Possible CSF pressure effects - GLP-1 receptors on the choroid plexus (where CSF is made) may reduce fluid secretion independent of weight loss The IIH Pressure Trial ( Brain , 2023) found that exenatide lowered intracranial pressure within hours of the first dose