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Reduced metabotropic glutamate receptor 5 density in major depression determined by [ 11 C]ABP688 PET and postmortem study

Cell cycle arrest: Metformin is also able to block glioma cells in specific cell cycle phases, such as G0/G1 or G2/M, by affecting the expression of cell cycle regulatory proteins

The aim of this review is to bring attention to the fact that subnormal levels of these enzymes should not be ignored as they may indicate pathological conditions and provide a means of early diagnosis