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These effects are dose-dependent: low to moderate doses mainly enhance adaptive stress responses through mild Nrf2 activation, while higher doses of concentrated alcoholic extracts produce stronger pharmacological effects by directly suppressing NF-B and intensifying Nrf2 activation [33]

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This complication was much more common with phenformin therapy, the initial biguanide, and the risk with metformin is estimated to be 20 times less (53)

Therefore, SGLT2 overexpression inhibition is a potential new target for highly prevalent hyperinsulinemia related conditions, namely some dysglycemic phenotypes and obesity