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A: The most common side effects are gastrointestinal, including nausea, constipation, feeling overly full, and temporary fatigue

Another animal study showed that inhibition of TMAO formation can upregulate the host hepatic bile acid synthetic enzyme CYP7A1 and alter the expression of hepatic genes critical for bile acid feedback regulation, thus preventing diet-driven hepatic cholesterol accumulation (Pathak et al., 2020)

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PMC 11751538