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CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling

Early intervention through supplementation, whether via B12 shots or IV infusions, helps prevent irreversible nerve damage

According to Mankin et al, the rigorousness of the OA destruction was categorized using the histologic standards (Table 2) based on structural variations (scale range 06), cellular variations (scale range 03), damage of safranin O staining (scale range 04) and tidemark integrity (scale range 01) by 3 independent researchers

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