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Given that FOXO4-DRI remains in the preclinical arena (i.e., animal models, in-vitro cell culture), lets review key studies and what they suggest

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Malabsorption disorders and IBD : Crohns, celiac, and other gastrointestinal disorders can cause damage to the intestinal lining, preventing the body from absorbing B12 and other nutrients effectively

Cardiovascular benefits: Clinical trials have demonstrated that tirzepatide can reduce the risk of major adverse cardiovascular events, such as heart attacks and strokes, in people with type 2 diabetes who have established cardiovascular disease