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This finding is remarkable because it suggests that the HPTA can be partially reactivated even in the presence of exogenous testosterone

Men on testosterone replacement therapy occupy a unique physiological space

Analgesic and others modulatory roles of melatonin The molecular pathways underlying the analgesic action of melatonin have not been completely addressed, and a plethora of mechanisms have been proposed, such as endorphin release from the pituitary gland 83 , modulation of the central GABAergic system 84 , and additional interaction with multiple receptor types