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Rivera K, et al

Protocol details: Initial phase dose: 20-30 ml per day Initial phase route: IV infusion (diluted in 100-250 ml saline) Initial duration: 14-21 days Maintenance dose: 10 ml per day Maintenance duration: 14 additional days Infusion time: 30-60 minutes (never rapid bolus at these doses) Expected timeline based on TBI trial data: Day 7-10: Improved neurological scores on GCS Day 21: Favorable GCS in treated patients with contusion and diffuse axonal injury Week 12: Significant cognitive improvement (CASI scores) in mild TBI Month 6: 67% achieved good outcomes (GOS 3-5) in moderate to severe cases Protocol 3: combination approach with donepezil Goal: Maximize cognitive benefit in established dementia through complementary mechanisms

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10.1089/zeb.2009.0639 10 CoffinA