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Targeting transporters: Promoting bloodbrain barrier repair in response to oxidative stress injury

At the level of expression regulation, Pickarts transcriptomic studies indicate that the compound affects the expression of hundreds of genes related to tissue repair, antioxidant defense and anti-inflammation in profile analyses, it acted as a modulator shifting the expression pattern towards the repair profile (Pickart et al

PARP-Mediated DNA Repair: Poly-ADP-ribose polymerases (PARPs), particularly PARP1, consume NAD+ as a substrate to detect and signal DNA damage and initiate repair

Levamisole, a therapeutic agent that specifically targets CD133, a recognized marker of OCSCs, has been developed (67)