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Since the carrier molecule of fatty acids, acyl-CoA, can not cross the cell membrane of the mitochondria, a deficiency of carnitine causes a reduction in the concentration of fatty acids in the mitochondria and, consequently, a reduced production of energy

Foretinib (EXEL-2880) also inhibits HGF-driven migration and invasion of murine B16F10 melanoma cells (value IC 50 of 21 nmol/L)