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Gil-Guzman E, Ollero M, Lopez MC, Sharma RK, Alvarez JG, Thomas AJ, Agarwal AP: Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation

The FDA has documented hospitalizations from dosing errors on this specific category of medication

If you experience nausea, constipation, or other gastrointestinal side effects, the standard medical approach is to pause dose escalation, manage symptoms with dietary changes and hydration, and allow your body more time at the current dose level