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Clinical trials indicate potential weight losses of 15% to 20% when semaglutide is coupled with lifestyle changes, underscoring its effectiveness

Together with glucagon (GCG) , they form an integrated hormonal network that maintains glucose and energy balance

Interestingly, we found 10 proteins involved in the fatty acid uptake, lipid storage, unsaturated fatty acid synthesis, lipid peroxidation, and glycerol efflux down-regulated in Sema/HFD group, including CD36 FABP5, ACSL, ACOX3, PLIN2, ANGPTL4, LPL, MGLL, AQP7, and PDK4 ( Figure 7 , Table 5 )