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Hypoglycemia represents a serious acute risk, as IGF-1 DES possesses potent insulin-like metabolic effects including enhanced glucose uptake into muscle and adipose tissue, increased glycogen synthesis, and suppression of hepatic glucose output

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Statins influence the activation of GTPases, such as Rho-GTPases, thereby regulating the transduction of PI3K/Akt/mTOR and ERK signaling pathways

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