tirzepatide discontinuation weight regain Possible Attenuation of Early Loss During Therapy in a Patient Treated With Levosulpiride: A Case Report and Mechanistic Hypothesis Rebound Weight Gain After Stopping

Infections : Tick-borne infections like Lyme disease , viral infections like Epstein-Barr, and gut infections like candida may lead to Hashimotos disease and an underactive thyroid

An analysis of 18 randomized control trials comparing the effects of GLP-1 RAs, SGLT-2 inhibitors, and Metformin demonstrated that semaglutide, dapagliflozin, ipragliflozin, and canagliflozin showed a significant weight loss in comparison with placebo treated controls (6)

The weight loss indication followed later, approved in the US as Zepbound in late 2023

(2006) Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes