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Although fMRI studies provide valuable non-invasive evidence that GLP-1RA treatment may alter neural responses to food-related cues, fMRI primarily measures blood-oxygen-level-dependent signals as an indirect index of neural activity, and therefore cannot determine whether GLP-1RAs act directly on specific central GLP-1R-expressing neuronal populations or indirectly through changes in peripheral physiology, interoceptive state, gastric emptying, or nausea-related signalling (98)