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The kidney-protective effects of GLP1-RAs are believed to result from reductions in inflammation and oxidative stress, in part through direct binding to glucagon-like peptide 1 (GLP1) receptors present on kidney glomerular and tubular cells [51]

But because obesity drives many of the major diseases of aging, including heart disease, cancer, dementia, arthritis and diabetes, the US Centers for Medicare and Medicaid Services says it makes sense to pilot a test to see whether the medications might ultimately save the program money and improve health outcomes

Garrod in his 1931 publication on inborn errors in metabolism