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Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status

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10.1016/j.jhazmat.2020.122052 195 TianY.ShangQ.LiangR.VilesJ

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Key administration points for the combination: Separate injection sites: Never inject both compounds at the same anatomical location

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