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Normal adjustment symptoms These are expected and typically manageable: loose stools 1 to 3 times daily during dose escalation, mild abdominal cramping before bowel movements, increased urgency (needing to go sooner than usual), softer stool consistency without other alarming features, symptoms that correlate with recent dose increases, and gradual improvement over 2 to 4 weeks at a stable dose

doi: 10.1056/NEJMoa1607141 18 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

In the SCALE trials, participants treated with Saxenda experienced average reductions of approximately 23 mmHg in systolic blood pressure compared with placebo

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