However, there are a few things to keep in mind when starting any new supplement
The combination is most useful for patients with one or more of the following: BMI of 30 or higher , or BMI 27 with at least one weight-related condition such as type 2 diabetes, hypertension, or sleep apnea History of fatigue, low mood, or brain fog on previous diets or weight loss attempts Metformin use for type 2 diabetes or pre-diabetes (chronic metformin reduces B12) Long-term proton pump inhibitor use such as omeprazole, pantoprazole, or lansoprazole Vegetarian or vegan diet with limited animal protein intake Adults over 50 , where B12 absorption naturally declines Active strength training or higher physical demands while on a calorie deficit Patients who dont fit any of these profiles can still take semaglutide alone, then add B12 if symptoms suggest it
Obesity and cancer
10.1002/ptr.8059 Summary Keywords nephroprotective effects, substances of medicine food homology, traditional Chinese medicine, phytochemicals, acute kidney injury Citation Chen L, Deng Y, Hu J and Gong X (2025) Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury
