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These agents have demonstrated robust efficacy in modulating metabolic dysfunctions central to MASLD progression, positioning them as a cornerstone in contemporary therapeutic strategies

For metastatic MMNST, ifosfamide plus doxorubicin is the most reported chemotherapy regimen, while fotemustine has shown partial remission in one case (23)

However, sustained glutamatergic over-activity might lead to excitotoxic damage resulting in residual negative symptoms, cognitive dysfunction, and occupational and social impairment [4]

220 Indeed, adenoviral TFEB overexpression via tail vein injection significantly alleviated alcohol-induced pancreatitis by reducing tissue injury, lowering serum amylase and lipase levels, and partially preserving lysosomal proteins