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Medical concepts are systematically categorized using the Medical Dictionary for Regulatory Activities (MedDRA) terminology, with Preferred Terms (PTs) representing granular AE descriptions, hierarchically grouped into High-Level Terms (HLTs), High-Level Group Terms (HLGTs), and System Organ Classes (SOCs) 18,19

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For patients meeting NICE criteria for weight management therapy (BMI 35 kg/m with adjustment for ethnicity, presence of weight-related comorbidities, and treatment through specialist weight management services), the dual benefit of weight reduction and blood pressure lowering may be particularly valuable