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Due to the observational study design, an inherent limitation was residual confounding by unmeasured confounders such as household annual income and other socioeconomic status, which might affect choice of diabetes medications and development of AF

This review synthesizes compelling evidence implicating a detrimental triad of interconnected biological processes, iron overload, cellular senescence, and fibrosis, as key contributors to the development, maintenance, and clinical manifestations of the disease (Fig