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Description

We focused on the changes within the endocrine population of the islet (Figure 3, A and B) and determined the proportion of , , and cells relative to total endocrine cells in each donor

Retatrutide is a triple-agonist medication, meaning it activates three hormone receptors involved in appetite and metabolism: GLP-1, GIP, and the glucagon receptor

This suggests that the drastic inhibition of GLP-1 secretion by shutdown of the main pathway via the SSTRs-Gi axis is the primary cause of pasireotide-induced hyperglycemia