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It was never going to be an anti-obesity drug. In mouse studies, AOD-9604 was shown to break down fat and prevent weight gain, but it was also shown that this effect over the longer term was dependent on a specific receptor When you give AOD-9604 to mice that are deficient in this receptor the weight-losing effect is lost. Its not surprising that AOD-9604 doesnt work in humans because the receptor on which it appears to be dependent is not the same in mice and humans. For anybody who knows anything about peptides used for fat-burning, the problem should have been obvious from the get-go

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Long-term data on semaglutide now extends beyond five years for diabetes indications and approximately three years for weight management, with ongoing extension studies continuing to accumulate evidence

These phosphatases might interrupt the c-MET signals by promoting dephosphorylation of catalytic or docking tyrosines