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Description

This age-related NAD+ depletion impairs mitochondrial energy production, reduces SIRT1 activity, compromises DNA repair mechanisms, and accelerates cellular senescence

PMC 12190491

DOI Booth SL, Golly I, Sacheck JM, et al

Common gastrointestinal effects are the most frequently reported adverse reactions, with studies reporting variable rates of digestive symptoms: Diarrhoea and loose stools Abdominal cramping and discomfort Constipation (less common) Nausea and bloating These effects are typically dose-dependent and may improve with gradual dose escalation or taking berberine with meals