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AOD 9604 has the stronger direct mechanistic argument for isolated fat loss: it mimics the lipolytic fragment of hGH without triggering anabolic or insulinogenic pathways, and it has Phase II human RCT data showing weight reduction, even if modest

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In that respect, the mathematical model suggests that this robustness may be inherently encoded in the negative feedback as the neural outputs were largely insensitive to a wide range of changes in the system's parameters (Appendix Fig S2)