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On February 18, 2025, we announced our decision to discontinue the development of SEP-786 and advance a next-generation oral small molecule PTH1R agonist

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Notably, GLP-1-producing neurons within the nucleus tractus solitarius (NTS) project axons to the VTA and other limbic structures, further embedding GLP-1 signaling within neural networks that regulate reward and motivation (Llewellyn-Smith et al., 2011

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