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( D ) Representative Western blots demonstrating that ALOX15 KD also decreases GPX4 protein expression ( n = 4)

Preclinical studies using in vitro-transcribed mRNA chimeric antigen receptor T cells (IVT mRNA CAR T) have shown effective, targeted cytotoxicity against various hematologic cancers, including CLL, acute lymphoblastic leukemia, and acute myeloid leukemia (AML), as well as solid tumors including mesothelioma, ovarian cancer, breast cancer, neuroblastoma, glioblastoma (GBM), and melanoma

Nevertheless, PS translocation to the outer leaflet of the phospholipid bilayer, a hallmark of eryptosis, can frequently occur without caspase-3 recruitment, primarily in response to Ca 2+ overload [84]

Zhang W, Zheng X, Chen X, Jiang X, Wang H, Zhang G (2023) Lead detoxification of edible fungi Auricularia auricula and Pleurotus ostreatus: the purification of the chelation substances and their effects on rats