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The published SURMOUNT-1 data in adults without diabetes over 72 weeks, per Eli Lilly's disclosed trial information: 5mg dose: average weight loss of 15.0% of body weight (approximately 34 lbs) 10mg dose: average weight loss of 19.5% of body weight (approximately 44 lbs) 15mg dose: average weight loss of 20.9% of body weight (approximately 48 lbs) Placebo: average weight loss of 3.1% (approximately 7 lbs) Average starting weights ranged from 226.8 to 233.3 lbs across dose groups

Breaking down the numbers further: 5% weight loss achieved : 95% with tirzepatide vs 79% with semaglutide 10% weight loss achieved : 89% with tirzepatide vs 61% with semaglutide 15% weight loss achieved : 77% with tirzepatide vs 39% with semaglutide 20% weight loss achieved : 62% with tirzepatide vs 23% with semaglutide Diabetes Management For patients with type 2 diabetes, both medications offer significant benefits, though tirzepatide shows a slight edge: HbA1c reduction : Tirzepatide typically lowers HbA1c by 2-2.5%, while semaglutide achieves 1-2% reduction Fasting glucose improvement : Both medications effectively lower fasting blood sugar Time in range : Patients on both medications spend more time with blood sugars in the target range Insulin sensitivity : Tirzepatide may provide greater improvements in insulin sensitivity Cardiovascular Benefits Semaglutide has established cardiovascular benefits with FDA approval for reducing heart attack, stroke, and cardiovascular death risk in patients with type 2 diabetes or obesity with established heart disease

Request your doctor include recent lab work showing glucose regulation status, metabolic panel results, and any cardiovascular risk factors