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Several studies show that it could be effective for some individuals with POTS if they have autoimmune activation of the angiotensin II receptor.[ref][ref][ref] Natural Supplements for POTS: Get enough B12 : One study noted that teens with POTS were about three times more likely to have low vitamin B12 levels.[ref] Good food sources of B12 include liver, fish, meat, poultry, eggs, and dairy products

Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure

With oral supplements, it can take weeks to feel a difference, especially if digestion is compromised

Direct binding normally requires separate tests designed to measure a physical interaction