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Use every night consistently for 4-6 weeks for best results

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Apply it generously to clean, dry skin, and allow the powerful ingredients to absorb and work their magic

Redox Biol 28:101343 Warren RB, Mrowietz U, von Kiedrowski R, Niesmann J, Wilsmann-Theis D, Ghoreschi K, Zschocke I, Falk TM, Bldorn-Schlicht N, Reich K (2017) An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial