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O efeito observado mediado pelo crescimento, no pela densidade

Bibcode:2009EnvMM..50..285S

5.11 Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin-containing products, including SOLIQUA 100/33

Its abundance was negatively correlated with body weight, adiposity index, liver index and triglycerides (TG) content, and multiple lipid marker levels in plasma, while positively correlated with short-chain fatty acids (SCFAs, such as acetate and propionate) and insulin levels, suggesting a central role in nicotine-mediated metabolic improvement