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Future research directions and policy decisions will determine whether these breakthrough therapies can meaningfully impact population health outcomes and reduce the substantial burden of obesity-related diseases ^42.

Reviews and clinical guidance emphasize dietary lactose reduction as first-line management, with lactase supplements as an adjunct when needed.11 22 Limiting alcohol and ultra-processed, high-fat foods can meaningfully reduce heartburn and reflux

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Location: On the head/neck or trunk: Slightly faster spread potential than limbs