The biodegradable, hydrophobic A polymer block comprises a polyester or poly(ortho ester), in which the polyester is synthesized from monomers selected from the group consisting of D,L-lactide, D-lactide, L-lactide, D,L-lactic acid, D-lactic acid, L-lactic acid, glycolide, glycolic acid, -caprolactone, -hydroxyhexanoic acid, -butyrolactone, -hydroxybutyric acid, -valerolactone, -hydroxyvaleric acid, hydroxybutyric acids, malic acid, and copolymers thereof and having an average molecular weight of between about 600 and 3000 Daltons
Topical formulations require penetration enhancers or vehicle optimization, and in vivo data suggest lower bioavailability compared to subcutaneous administration
However, the risk of cholelithiasis, micronutrient deficiencies and lean muscle mass loss during the rapid WL phase are of particular concern with the new obesity treatments
How may GIP Enhance the therapeutic efficacy of GLP-1