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On average, the drugs cost $1,540 per prescription, but patients paid an average of just under $35 out-of-pocket for each prescription

Tirzepatide stands out because its anti-inflammatory effects are not its primary mechanism, they are a beneficial secondary effect that amplifies its primary actions across every organ system it touches

This broader lens would enable a more holistic and impartial appraisal of investigational therapies, capturing cardiovascular, renal, and metabolic endpoints in addition to traditional histologic markers of liver injury, so that therapeutic value is not judged solely on liver-specific surrogates [53]

That practicality is part of why it has held up as a first-line option for so long