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While tirzepatide does not directly cause thyroid dysfunction, weight loss and metabolic changes can sometimes unmask subclinical thyroid disease

Additionally, catalpol protects against Triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the protein kinase RNA-like endoplasmic reticulum kinase (PERK)/Activating Transcription Factor 4 (ATF4)/CHOP pathway, reversing liver function indices, autophagy levels, and apoptotic protein expression (Zhang L

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