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doi:10.2147/CEG.S234698

The SURMOUNT-5 trial showed that maximum-dose tirzepatide produces about 47% more weight loss than maximum-dose semaglutide, so they are clearly not equivalent at their respective maximums

Anyway, a state of relative insuficiency may persist for several months after the discontinuation of the therapy, so any stress that occurs in this period requires reinstituting corticosteorid therapy or dose increase

For chronic joint pain and systemic inflammation, we typically recommend an initial series of 3 to 6 sessions over 2 to 4 weeks to restore cellular levels