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Inhibition of GPX4 enzymatic activity, either through directly damage to the selenocysteine site or indirectly by suppressing system xc-, leads to reduced GSH levels and the propagation of lipid peroxidation
de la Torre et al., Two main pathways are involved in MDMA metabolic clearance: (1) O-demethylenation partially regulated by CYP2D6 followed by catechol-O-methyltransferase (COMT)-catalyzed methylation (HMMA) and/or glucuronide/sulfate conjugation
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