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Multivitamins, particularly those high in B vitamins, frequently cause bright yellow urine

Additionally, the lack of federal regulatory oversight around compounded peptide products which are not subject to the same strict manufacturing and purity standards as FDA-approved drugs allows for safety concerns, such as potential risks of sterility issues, inaccurate dosages, unknown side effects, and product contamination

However, a mutation in the transcription factor KLF1 that regulates PKLR transcription is a rare cause of PK deficiency (see below)

Most patients check in monthly during the first few months, then every 6-8 weeks once they're stable on their maintenance dose