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In vivo , knockdown of LPCAT3 aggravates OA progression and inflammation, while pharmacological inhibition of ACSL4 partially rescues these effects (76)

Key Takeaways The most common side effects are digestive issues like nausea, diarrhoea, vomiting, and constipation, similar to other GLP-1 medications Some participants experienced mild increases in heart rate at higher doses, but this decreased over time Side effects are typically worse when starting treatment or increasing doses, then improve as your body adjusts Long-term side effects are unknown as trials have only lasted up to one year so far Retatrutide is still in clinical trials and not available for prescription yet By entering I agree to the Terms and Conditions

The injection site information in this article reflects general clinical practices for subcutaneous GLP-1 medications

Klein JC, Lajoie MJ, Schwartz JJ, Strauch EM, Nelson J, et al