The PPP supplies the RBC with NADPH to maintain the reduced state of glutathione
Therapeutic strategy focusing on the ferroptosis pathway SLC7A11, a molecule that protects cancer cells from ferroptosis-induced cell death, is overexpressed in different types of cancers, including ovarian cancer, lung cancer, triple-negative breast cancer, PDAC, renal cell carcinoma, liver cancer, and glioma, and it is associated with aggressive phenotypes and poor prognosis [16,46,89]
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases
It is not very stable either, when exposed to sunlight, it kind of breaks down and loses its effectiveness (not instantly, but over time - it loses 10% of its SPF protection ability within 35 mins)