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Glutathione is a crucial guardian of protein integrity in the brain upon nitric oxide imbalance

3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems

doi: 10.1186/s41983-018-0033-z 24

However, due to the off-target effect as a multi-kinase inhibitor [8], therapeutic advances are directed toward targeting metabolic vulnerabilities associated with SLC7A11 pathways in cancer